Automated Skin Cell Suspension Autograft Procedures

Question:

A provider at our facility has begun performing the new 2025 skin cell suspension autograft procedure. During this process, automated preparation of the autograft is performed, including enzymatic processing, disaggregation of skin cells, and filtration of harvested tissue. Currently, there is no specific CPT code that describes this work. Since we are advised to report an unlisted code for this service, what comparative CPT code would you recommend using to help determine appropriate reimbursement?

Answer:

Typically, 15271 (application of skin substitute graft, first 25 sq cm or less) or 15272 (each additional 25 sq cm) for larger surface areas are considered reasonable comparisons, as these codes reflect the time, effort, and wound care intensity associated with the application process. However, these comparison codes do not account for the additional physician work involved in the enzymatic and cellular processing of the harvested skin cells, which includes preparation, disaggregation, and filtration prior to application. The most appropriate comparison code and valuation should therefore be determined based on the specific details outlined in the procedure note. Additional coding may include 15002–15005 for recipient site preparation or 15040–15261 for additional grafts when performed.

*This response is based on the best information available as of 11/06/25.